These Rectal and Vaginal Suppositories are a great alternative to medicate. The answer to your pain, Men and Women depending on your ailment. other routes of medicating can be impossible or even uncomfortable. Some other advantages include: faster onset, bypasses about 2/3 of first-past metabolism, less nausea than edible route, less psychoactive effects than oral or inhaled routes and easier administration in palliative/hospital/home environments. Box contains 4 units.